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Beckman Coulter OSR6160 Olympus C4 Reagent (Complement 4 Reagent)


Intended Use

OSR6160 Olympus C4 reagent, also known as Complement 4 Reagent is used for the quantitative determination of Complement 4 (C4) in human serum on Beckman Coulter AU analyzers.

Brand: Beckman Coulter
Manufacturer SKU: OSR6160
Analyzer Type: Chemistry Analyzer
Analyzer Series: AU Analyzer Series
Test Type: Immunochemistry / Specific Protein Test
Test Name: Complement C4
SKU: OSR6160 Category:


Beckman Coulter OSR6160 Olympus C4 Reagent (Complement 4 Reagent for Complement C4 Test) Specifications:

Beckman Coulter OSR6160 Olympus C4 Reagent (Complement 4 Reagent for Complement C4 Test)

C4 (Complement 4) is part of the Complement system, a group of proteins in the blood that play a role in inflammation. It’s specifically involved in the classical complement pathway, meaning its levels decrease only when this pathway is active. In diseases where only the alternate pathway is activated, C4 levels remain normal. Testing C4 levels helps diagnose immune disorders, especially those related to complement deficiencies.

Beckman Coulter OSR6160 Olympus C4 Reagent (Complement 4 Reagent for Complement C4 Test) Methodology

The Olympus C4 reagent test relies on measuring how light scatters when immune complexes form in a solution. Turbidimeters gauge the reduction of light due to various factors like reflection, absorption, or scatter.

During the test, the decrease in transmitted light (or increase in absorbance) caused by particles in the solution forming complexes during the antigen-antibody reaction serves as the basis for analysis.

What Is a Complement 4 Test / Complement C4 Test ?
A complement C4 (also known as a complement component 4, or simply C4) is a test to measure the level of C4 proteins you have in your blood. These proteins play a role in how your immune system functions and defends your body from harmful bacteria and viruses.Monitoring your C4 protein levels can help doctors to diagnose and monitor certain chronic medical conditions. Here is what you need to know about complement component 4 proteins, who can benefit from a C4 complement blood test, and information about C4 test results.

Complement component 4 (C4) is a type of special protein that is found on the surface of certain cells and in blood plasma. It is part of a group of almost 60 proteins that make up your complement system that works alongside your immune system. These complement proteins help to fight viral and bacterial infections and rid your body of dead cells and other foreign material.

Rarely, genetic variations can cause some people to have lower levels of C4 protein, which gives them a greater risk of developing infections and some types of autoimmune diseases like lupus, rheumatoid arthritis, and systemic sclerosis.

Doctors use information from C4 test results to gauge how people with some chronic diseases or autoimmune disorders are responding to treatments or to help them diagnose certain diseases.

C4 test is useful because after an injury, illness, or infection when your body is actively fighting inflammation the amount of C4 protein in your blood changes.

Your doctor might also want you to take a C4 test if you show signs of chronic infections, kidney problems, hepatitis, or autoimmune diseases like rheumatoid arthritis and lupus.

Lupus can cause rashes, fevers, joint pain, and organ damage. There is currently no cure for lupus, and treatment focuses on managing symptoms to reduce inflammation.

If you have lupus, your doctor might order a C4 test to see how well your body is responding to treatment. People with lupus will have low levels of complement C4 protein during flare-ups. These levels increase to a normal range after the inflammation passes.

Beckman Coulter OSR6160 Olympus C4 Reagent Complement 4 Reagent for Complement C4 Test | JIT4You Clinical Lab Consumables
Beckman Coulter OSR6160 Olympus C4 Reagent Complement 4 Reagent for Complement C4 Test

A normal range for C4 test results is between 15 and 45 milligrams per deciliter. This range might differ slightly depending on the measurements and specimens used to complete the test. Make sure to talk with your doctor about your results and what they might mean based on your medical history.

Low complement C4 levels under 15 milligrams per deciliter might indicate some types of health problems and conditions such as:


  • Malnutrition
  • Lupus
  • Liver diseases such as hepatitis and cirrhosis
  • Inherited genetic deficiencies
  • Hereditary angioedema (swelling under the skin)
  • Certain kidney diseases or kidney rejection after a transplant
  • Childhood diseases like diabetes mellitus and Henoch-Shonlein purpura