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Beckman Coulter 33530 Access Prolactin Reagent, 100 Determinations


Analyzer Series: Access Analyzer Series, Synchron LXI Analyzer Series, UniCel DXI Analyzer Series
Brand: Beckman Coulter
Manufacturer SKU: 33530
Package Size: 2 x 50 Tests
Test Type: Reproductive Hormone Assay
Test Name: Prolactin
Analyzer Type: Hematology Analayzer
SKU: 33530 Category:


Beckman Coulter 33530 Access Prolactin Reagent (PRL) Specifications:

  • Brand: Access®
  • Manufacturer: Beckman Coulter 33530
  • Country of Origin: United States
  • Application: Reagent, Rental
  • For Use With: For Access 2, Unicel DXI, Synchron LXI Systems
  • Number of Tests: 100 Tests
  • Test Name: Prolactin Test
  • Test Type: Reproductive Hormone Assay
Beckman Coulter 33530 Access Prolactin Reagent (Prolactin Test): INTENDED USE

The Access Prolactin assay is a paramagnetic particle, chemiluminescent immunoassay for the quantitative determination of prolactin levels in human serum and plasma (heparin) using the Access Immunoassay Systems.

Access Prolactin Reagent (Prolactin Test): SUMMARY AND EXPLANATION

Prolactin is a single chain polypeptide composed of 198 amino acids with three inter-chain disulfide bonds and a molecular weight of approximately 22,500 daltons. secreted by the anterior cells of the pituitary gland. Prolactin secretion is controlled by the hypothalamus primarily through the release of prolactin inhibiting factor (dopamine) and prolactin releasing factor (serotonin). Thyrotropin releasing hormone (TRH) stimulates PRL secretion and is useful as a provocative test to evaluate PRL reserves and abnormal secretion of PRL by the pituitary.

The primary physiological function of Prolactin is to stimulate and maintain lactation in women. In normal females, serum PRL levels generally range from 1-25 ng/mL (µg/L) while normal male levels typically range from 1-20 ng/mL (µg/L). Normal Prolactin secretion varies with time which results in serum PRL levels 2-3 times higher at night than during the day. The biological half-life of Prolactin is approximately 20-50 minutes. Serum PRL levels during the menstrual cycle are variable and commonly exhibit slight elevations during the mid-cycle. Prolactin levels in normal individuals tend to rise in response to physiologic stimuli including: sleep, exercise, nipple stimulation, sexual intercourse, hypoglycemia, pregnancy, and surgical stress.

Prolactin is secreted by the anterior pituitary gland and is required for normal breast development and lactation in women. Elevated Prolactin levels may be detected during the eighth week of pregnancy with levels continuing to rise throughout gestation. In the absence of breast feeding, Prolactin levels return to normal within three weeks after birth. Abnormally high levels of PRL are often associated with female infertility, impotence and infertility in men, primary hypothyroidism, and pituitary tumors.

Prolactin levels are elevated post-partum and in newborns. Prolactin deficiencies in normal individuals are rare. Pathologic causes of hyper-prolactinemia include: PRL secreting pituitary adenomas (prolactinomas), functional and organic diseases of the hypothalamus, hypothyroidism, renal failure, and ectopic tumors. Elevated levels of PRL may be observed in cases of primary hypothyroidism due to an increased secretion of TRH (stimulates PRL release) accompanied by decreased serum T4 levels and increased serum thyroid stimulating hormone concentrations. Hyper-prolactinemia has also been associated with the inhibition of ovarian steroidgenesis, follicle maturation, and secretion of luteinizing hormone and follicle stimulating hormone.


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