Beckman Coulter 37215 Access Hybritech free PSA Calibrators (S0-S5)

Description

Beckman Coulter 37215 Access Hybritech free PSA Calibrator (Free PSA test) specifications:

• Brand: Access Hybritech
• Manufacturer: Beckman Coulter 37215
• Country of Origin: United States
• Application: Calibrator
• Storage Requirements: USP Controlled Room Temperature
• Test Name: Prostate Specific Antigen (PSA Test)
• Test Type: Cancer Immunoassay
• Data Sheet
• Other related products:
  • 1. Beckman Coulter 37200 Access Hybritech PSA, 100 Determinations
  • 2. Beckman Coulter 37205 Access Hybritech PSA Calibrator (S0-S5)
  • 3. Beckman Coulter 37210 Access Hybritech free-PSA Reagent, 100 Determinations

Beckman Coulter 37215 Calibrator: INTENDED USE

The Access Hybritech free PSA Calibrators are intended to calibrate the Access Hybritech free PSA assay for the quantitative determination of free-PSA levels in human serum using the Access Immunoassay Systems.

Beckman Coulter 37215 Access Hybritech free PSA Calibrator SUMMARY AND EXPLANATION:

Quantitative assay calibration is the process by which samples with known analyte concentrations (i.e., assay calibrators) are tested like patient samples to measure the response. The mathematical relationship between the measured responses and the known analyte concentrations establishes the calibration curve. This mathematical relationship, or calibration curve, is used to convert RLU (Relative Light Unit) measurements of patient samples to specific quantitative analyte concentrations.

Beckman Coulter 37215 Access Hybritech free PSA Calibrator: About Free PSA

 

A free prostate-specific antigen (PSA) test is used to confirm test results from a PSA test. A PSA test is used to see if you may have prostate cancer. The test measures the level of PSA in your blood. If your levels are high, you may have a condition that’s not serious, such as a prostate that’s enlarged or inflamed prostate, or you might have prostate cancer. A free PSA test may be used instead of a biopsy to rule out prostate cancer, though you may still need a biopsy if your free-PSA test results indicate a risk of cancer.

PSA is an enzyme that binds to proteins in semen and breaks them down. This makes the semen more liquid. Semen that’s more liquid can more easily move sperm to a woman’s fallopian tubes during the reproductive process.

PSA is produced mainly in your prostate gland and is released into your semen. During ejaculation, some PSA passes into your bloodstream through the rich blood supply of the prostate. Two types of PSA circulate in your body:

 

 

• Free-PSA is PSA that hasn’t bound to any proteins.
• Bound PSA is PSA that has bound to proteins.

When your PSA is tested, it may be measured two ways:

• A free-PSA test measures only the unbound PSA in your bloodstream.
• A PSA test measures your total PSA, meaning both your bound and free.

The free PSA test is sometimes given instead of a biopsy if your PSA levels are slightly elevated. It also may be used to give your doctor an idea of how aggressive the cancer is if your cancer has returned after treatment.

PSA is tested by taking a sample of blood, usually from your arm. The sample will be sent to a laboratory for testing and the results will be given to your doctor.

PSA testing has a number of limitations.

• The PSA test is known to have a high rate of false positives.
• It’s not uncommon for a man to have prostate cancer when his PSA is below the limits that indicate there might be cancer.
• About 75 percent of men who have an elevated PSA do not have cancer.
• Normal PSA ranges were established primarily on white males, though PSA levels may vary depending on a man’s ethnicity.
• There can be changes in PSA levels if they’re tested by a different lab or technicians use different testing methods.

Beckman Coulter 37215 Access Hybritech free PSA Calibrator: PSA levels by age

Following are normal PSA levels by age:

Beckman Coulter 37215 Access Hybritech free PSA Calibrator: Free PSA

Free-PSA is measured as the proportion of free-PSA to total PSA. Below is a table outlining the likelihood of finding prostate cancer based on the percentage of free-PSA in men with a total PSA between 4ng/mL and 10 ng/mL, according to the Journal of American Medical AssociationTrusted Source.