Beckman Coulter OSR6143 Apo B Reagent Specific Protein Apolipoprotein B (Apo B)

Beckman Coulter OSR6143 Apo B Reagent – Specific Protein Apolipoprotein B Test (Apo B Test) Specifications:

• Manufacturer: Beckman Coulter OSR6143
• Country of Origin: Ireland
• Application: Apo B Reagent
• Number of Tests: 4 X 250 Tests
• Test Method: Immunoturbidimetric Method
• Test Name: Apolipoprotein B Test / Apo B Test
• UNSPSC Code: 41116004
• Test Type: Cardiac / Specific Protein Test
• Volume: 4 X 13 mL, 4 X 7 mL
• Data Sheet
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Beckman Coulter OSR6143 Apo B Reagent – Specific Protein Apolipoprotein B Test (Apo B Test): Intended Use

System reagent for the quantitative determination of Apolipoprotein B in human serum on Beckman Coulter AU analyzers.

About Beckman Coulter OSR6143 Apo B Reagent – Specific Protein Apolipoprotein B Test (Apo B Test)

Lipids are transported throughout the body by complex structures called lipoproteins. Lipoproteins are classified into five major density classes: chylomicrons, very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), low density lipoprotein (LDL) and high density lipoprotein (HDL). Over the past several decades, decreased serum levels of high density lipoprotein (HDL) and increased levels of low density lipoprotein (LDL) have been associated with increased risk of coronary artery disease.

Associated with these lipoproteins, at least five major apolipoproteins have been described and have been labeled A through E. Apolipoprotein B (Apo-B) is the major protein component of VLDL and LDL, and therefore plays an essential role in lipid transport and metabolism.

Beckman Coulter OSR6143 Apo B Reagent – Specific Protein Apolipoprotein B Test (Apo B Test): Methodology

Immune complexes formed in solution scatter light in proportion to their size, shape and concentration. Turbidimeters measure the reduction of incidence light due to reflection, absorption or scatter.

In this procedure, the decrease in intensity of light transmitted (increase in absorbance) through particles suspended in solution is the result of complexes formed during the antigen-antibody reaction.

What is an Apo B test?

An Apo-B or Apolipoprotein B-100 test is a blood test that can tell you about your risk for cardiovascular (heart and blood vessel) disease. To do this, it measures the amount of Apo-B, which carries substances in your blood that help make plaque, a waxy fat that can block your arteries.

Apolipoprotein B takes lipids where they’re going. But it only gives rides to the kind of lipids that have a bad reputation: low-density lipoprotein (LDL), very low-density lipoprotein (VLDL) and others. You won’t find the good cholesterol, high-density lipoproteins (HDL), hanging around with Apo-B. When you see Apo-B, you can be sure LDL is there, too.

Some healthcare providers believe an Apo B test is more accurate than a lipid panel (which measures all those cholesterol types) to estimate cardiovascular disease risk.

When is an Apo B test performed?

Healthcare providers can order an ApoB test when they want an additional way to measure your cardiovascular disease risk. Having another option can give them more information if you didn’t come out high or low in the usual risk factors. Also, they may want to order the test after you start taking a statin to lower your bad cholesterol.

Researchers have found that measuring Apo-B may predict heart and blood vessel disease risk better than a lipid panel test. This is because each Apo-B molecule carries one of the bad lipoproteins. They can get an accurate count because of the one-to-one ratio.

Providers can subtract your HDL cholesterol from your total cholesterol from lipid panel results as a way to predict cardiovascular disease. But this isn’t accurate for everyone. Apo-B testing can be a better risk predictor for people with metabolic syndrome or diabetes because their LDL may be denser or smaller.