Beckman Coulter ODR3023 Olympus Serum Protein Multi Calibrator 2

Description

Beckman Coulter ODR3023 Olympus Serum Protein Multi Calibrator (Acidglyco Test, Antitrypsin Test, Microglobulin Test, Ceruloplasmin Test and Haptoglobin Test)

Specifications:

• Manufacturer: Beckman Coulter ODR3023
• Application: Multi Calibrator
• Levels: Level 2
• Test Name: Serum Protein (Acidglyco Test, Antitrypsin Test, Microglobulin Test, Ceruloplasmin Test and Haptoglobin Test)
• Storage Requirements: Store at 2 to 8°C
• Volume: 5 X 2 mL
• Data Sheet
• Related Products
  • Beckman Coulter ODR3021 Olympus Serum Protein Multi Calibrator

Product Description

The olympus Serum Protein Multi-Calibrator 2 is intended to be used with the Beckman Coulter immuno-turbidimetric reagents for the quantitative determination of -1 acidglyco protein, -1 antitrypsin, -2 microglobulin, ceruloplasmin and haptoglobin on Beckman Coulter analyzers. The material is prepared from human serum with the constituent values adjusted where necessary by the addition of analytical grade chemicals and appropriate serum proteins.
Amber; Clear; Liquid; Mild odor

Acidglyco Test

alpha(1)-Acid glycoprotein (AGP) is a protein with a molecular weight of 41-43 kDa and is heavily glycosylated (45%). Due to the presence of sialic acids, it is negatively charged (pI=2.7-3.2). AGP is an acute phase protein in all mammals investigated to date. The serum concentration of AGP rises several fold during an acute phase response, the systemic answer to a local inflammatory stimulus. Also, its glycosylation pattern can change depending on the type of inflammation. The biological function of this protein is not clear. A number of activities on different type of blood cells have been described. In vivo, AGP clearly has protective effects in several models of inflammation. Here we review the data supporting an anti-inflammatory and immunomodulating role of AGP.

Antitrypsin Test

 

Alpha-1 antitrypsin (AAT), Antitrypsin Test uses a sample of blood or a cheek swab to diagnose a condition called alpha-1 antitrypsin deficiency (AAT deficiency). This condition is sometimes known as “alpha-.” or AATD. If you have AAT deficiency, your body doesn’t make enough AAT.

AAT is made by your liver. It helps protect your lungs from inflammation and irritating substances you might breathe in, such as smoke. If your liver doesn’t make enough AAT, your lungs may be more easily damaged from smoking, pollution, or dust from the environment. This can lead to a serious lung condition called chronic obstructive pulmonary disease (COPD). AAT deficiency may also cause a liver disease called cirrhosis. This is more common in children who have AAT deficiency.

AAT deficiency is a genetic disorder. That means it’s caused by changes in your genes, which may also be called gene variants or mutations.

Genes carry information that controls what you look like and how your body works. AAT deficiency is caused by changes in the SERPINA1 gene, which carries instructions for making the AAT protein. These gene changes are inherited from your parents, so AAT deficiency tends to run in families.

If you have two mutated copies of the gene, it means you have a condition called AAT deficiency. People with this disorder have a higher risk of getting lung disease or liver damage before the age of 45.
If you have one mutated copy of the gene, you are a carrier of AAT deficiency. In these cases, this means you are at slightly higher risk of developing lung disease, especially if you other risk factors, such as being a smoker. You could pass the mutated gene on to your children.
There are a few gene changes that cause AAT deficiency. These gene changes can:

Decrease the amount of AAT protein your liver makes.
Prevent your liver from making any AAT.

There are three types of testing to help diagnose AAT deficiency:

Antitrypsin Test measures the amount of protein found in your blood to see if your AAT levels are abnormal.
If your Antitrypsin Test levels are abnormally low, a genetic test (either a genotype test or a phenotype test) is needed to confirm a diagnosis of AAT deficiency.

Other names: A1AT, AAT, alpha-1-antiprotease deficiency, α1-antitrypsin, serum AAT test, AAT phenotyping, AAT genotyping, AAT deficiency test, AAT DNA sequencing test, AAT isoelectric focusing test, A1AT test, AATD test, alpha-1, Antitrypsin Test, protease inhibitor deficiency test

Microglobulin Test

A beta-2 microglobulin tumor marker test (Microglobulin Test) measures the amount of a protein called beta-2 microglobulin (B2M) in your body fluids. The Microglobulin Test usually uses a sample of your blood. It may also be done using urine (pee) or in rare cases cerebrospinal fluid (CSF).

B2M is a type of tumor marker. Tumor markers are substances that are often made by cancer cells or by normal cells in response to cancer in the body. B2M is found on most of the cells in your body. Normally, you have only small amounts of B2M in your blood and urine. High levels of B2M in body fluids are often caused by these blood and bone marrow cancers:

• Multiple myeloma
• Chronic lymphocytic leukemia (CLL)
• Certain types of lymphoma

 

Other names: total beta-2 microglobulin, β2-microglobulin, B2M, B2MG, thymotaxin, Microglobulin Test.

Ceruloplasmin Test

The Ceruloplasmin Test is used to measure how much of a copper-containing protein is in your blood. Ceruloplasmin Test is used to diagnose problems related to copper, such as Wilson disease. Wilson disease is a rare inherited disease. It causes too much copper in your blood.

Ceruloplasmin is a protein made in your liver. It stores and carries the mineral copper around your body. Ceruloplasmin carries 65% to 90% of the copper found in blood. Copper is vital to many processes in your body. These include building strong bones and making melanin. But having too much copper in your body can be toxic.

Your liver normally takes copper from your bloodstream and puts it into ceruloplasmin proteins. The ceruloplasmin is then released into blood plasma. Ceruloplasmin carries copper around your body to the tissues that need it.

In Wilson disease, copper is not put in ceruloplasmin. The disease also keeps your liver from sending extra copper to be eliminated in your bowel movements. Instead, copper builds up in your liver until it overflows into the bloodstream. From there, copper builds up in your brain, corneas, kidneys, liver, bones, and small glands near the thyroid. If not treated, the liver and brain damage due to copper poisoning from Wilson disease is fatal.

Haptoglobin Test

The Haptoglobin Test measures the level of a protein in your blood called haptoglobin.

Haptoglobin is made by your liver. It binds to a type of hemoglobin that’s made when red blood cells die, leading to anemia. This haptoglobin-hemoglobin complex is removed from your body by your liver. If too much hemoglobin is bound to haptoglobin, the levels of haptoglobin will drop. The level of haptoglobin in your blood helps your healthcare provider figure out what type of anemia you have.

Haptoglobin Test results may vary depending on your age, gender, health history, and other things. Your Haptoglobin test results may be different depending on the lab used. They may not mean you have a problem.