Beckman Coulter B84493 Access Sensitive Estradiol Reagent
$276.20
Brand: Beckman CoulterTest Name: Estradiol
Article Number: B84493
- Description
Description
Beckman Coulter B84493 Access Sensitive Estradiol Reagent (Estradiol Test) Specifications:
- Brand: Access
- Manufacturer: Beckman Coulter B84493
- Country of Origin: Ireland
- Application: Access Reagent
- Container Type: Well
- For Use With: For use with Access Immunoassay Systems
- Sample Type: Human Serum / Plasma Sample
- Test Method: Competitive Immunoassay
- Test Name: Estradiol Test
- Number of Tests: 2 X 5Tests
- Test Type: Reproductive Endocrinology Assay
- Beckman Coulter B84493 Data Sheet
- Related products:
Beckman Coulter B84493 Access Sensitive Estradiol Reagent (Estradiol Test): INTENDED USE
The Access Sensitive Estradiol assay is a paramagnetic particle, chemiluminescent immunoassay for the quantitative determination of estradiol levels in human serum and plasma using the Access Immunoassay Systems.
Beckman Coulter B84493 Access Sensitive Estradiol Reagent (Estradiol Test): SUMMARY AND EXPLANATION
Estradiol reagent (17?-estradiol) is a natural estrogen with a molecular mass of 272.4 daltons. Most circulating estradiol is strongly bound to sex hormone binding protein and loosely bound to albumin. It is estimated that only 1-5% of estradiol is free (unbound). In non-pregnant women, estradiol is secreted by the ovary and the corpus luteum.
The adrenals and testes (in men) are also believed to secrete minute amounts of estradiol.Estradiol levels are lowest at menses and into the early follicular phase and rise in the late follicular phase to a peak just prior to the hLH (human Luteinizing Hormone) surge, initiating ovulation. As the hLH peaks, the levels of estradiol decrease before rising again in the luteal phase. Endometrial growth is stimulated by estradiol and progesterone (secreted by the corpus luteum) in preparation for implantation of a fertilized egg.
If conception does not occur, the secretion of estradiol and progesterone by the corpus luteum decreases, initiating menses.Levels of estradiol are used to monitor ovulatory status. Because estradiol levels reflect follicular maturation, the measurement of estradiol as cited in the scientific literature has been used as a valuable tool in the assessment of sexual development in children, anovulation and/or amenorrhea, polycystic ovary syndrome and causes of infertility and menopause.
During in vitro fertilization, estradiol levels are routinely measured after gonadotropin stimulation to determine follicular status. Estradiol also affects areas other than reproductive tissues such as cardiovascular, immune and central nervous systems. For this reason estrogen has been investigated in the pathogenesis of cardiovascular disease, hormone-dependent cancers and osteoporotic fracture. Abnormally high levels in males are indicative of feminizing syndromes such as gynecomastia.
What is an estradiol test and why is it used?
An estradiol (E2) test measures levels of the hormone E2 in the blood. The results can reflect issues ranging from fertility problems to liver damage.
The right estrogen levels are essential for reproductive health. Having too much or too little estrogen can also lead to medical problems, such as weak bones, urinary tract infections, and even depression.
Doctors may order an estradiol test if they are concerned about a person’s fertility, puberty, or menopause. In this article, we examine when a doctor might order this test, what the results can mean, and what to expect during and after the test.
