Description

Beckman Coulter OSR61205 UIBC unsaturated reagent (uibc reagent) iron binding capacity Specifications:

• Manufacturer: Beckman Coulter OSR61205
• Country of Origin: Ireland
• Application: UIBC Unsaturated Reagent
• Number of Tests: 4 X 240 Tests
• Test Name: Unsaturated Iron Binding Capacity (UIBC)
• Test Type: General Chemistry
• UNSPSC Code: 41116004
• Volume: 4 X 27 mL, 4 X 3 mL, 4 X 6 mL, 4 X 2 mL

About Beckman Coulter OSR61205 UIBC Reagent (Unsaturated reagent Iron Binding Capacity)

Iron (non-heme) measurements are used in the diagnosis and treatment of diseases such as iron deficiency anemia, hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin), and chronic renal disease. Transferrin is the major iron carrying protein in the serum. Serum iron concentration connotes the Fe (III) bound to serum transferrin and does not include the iron contained in serum as free hemoglobin. Because normally only about one third of the iron binding sites of transferrin are occupied by Fe (III), serum transferrin has considerable reserve Iron Binding Capacity. This is called the serum Unsaturated Iron Binding Capacity (UIBC).

Methodology: Beckman Coulter OSR61205 UIBC Reagent (unsaturated reagent):

In this UIBC procedure intended for use on the Beckman Coulter automated AU analyzers, ferrous-Iron (Fe2+) at alkaline pH, added to serum, binds specifically with transferrin at unsaturated iron binding sites. Remaining unbound ferrous iron reacts with the Nitroso-PSAP [2-Nitroso-5-(N-propyl-Nsulfopropylamino)phenol] to form an intense green complex. The difference between the resulting change in the measured absorbance and the absorbance from the total amount added to serum is equivalent to the quantity bound to transferrin. This is the Unsaturated Iron Binding Capacity (UIBC).