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Beckman Coulter OSR6211 Olympus Direct Bilirubin Reagent (DBil) 4×200 tests


Intended Use

System reagent for the quantitative determination of Direct Bilirubin in human serum and plasma on Beckman Coulter AU analyzers.
*Direct Bilirubin reagent OSR6511 for use on AU2700/5400/680 system only.

Brand: Beckman Coulter
Manufacturer SKU: OSR6211
Analyzer Type: Chemistry Analyzer
Analyzer Series: AU Analyzer Series
Test Type: Hepatic
Test Name: Direct Bilirubin
SKU: OSR6211 Category:


Beckman Coulter OSR6211 Olympus Direct Bilirubin Reagent (Olympus DBil reagent for Direct Bilirubin Test):

About Beckman Coulter OSR6211 Olympus Direct Bilirubin Reagent (Olympus DBil reagent for Direct Bilirubin Test)

Bilirubin is an end product of hemoglobin catabolism. It is conjugated with glucuronic acid in the liver, and the conjugated form is cleared from the circulation by excretion in the bile. Both conjugated (direct) and unconjugated (indirect) forms of bilirubin circulate loosely bound to albumin.
The assessment of DBil is helpful in the determination of hepatic disorders. The increase in the total bilirubin associated with obstructive jaundice is primarily due to the direct fraction

Both direct and indirect bilirubin are increased in the serum with hepatitis. In the newborn patient with hemolytic jaundice and neonatal jaundice, the increase in the total bilirubin is primarily due to the indirect bilirubin fraction. This jaundice may be caused by Rh, ABO, or other blood group incompatibilities, by hepatic immaturity, or by hereditary defects in bilirubin conjugation.

Beckman Coulter OSR6211 Olympus Direct Bilirubin Reagent (Olympus DBil reagent for Direct Bilirubin Test): Methodology

The beckman coulter OSR6211 Olympus Direct Bilirubin Reagent (Olympus DBil),  utilizes a variation of the classical method developed by Van den Bergh and Mueller. Direct (conjugated) bilirubin couples directly with a diazonium salt of 3,5-dichloroaniline (DPD) in an acid medium to form azobilirubin.
The Olympus DBil in serum is directly proportional to the color development of azobilirubin which is measured bichromatically at 570/660 nm.

What is bilirubin?

Bilirubin is a byproduct of broken-down old red blood cells. When red blood cells finish their life cycles in your body, they break down and pass through your bloodstream to your liver for processing. Your liver sorts bilirubin with other waste products into a fluid called bile. Bile exits your body through your intestines. Bilirubin is the pigment that gives bile its distinctive yellow color. It also colors your poop.

What is a Direct Bilirubin Test?

A bilirubin blood test measures bilirubin levels in your blood. A healthcare provider draws a small sample of your blood from a vein and sends it to a lab to analyze. The lab will measure your bilirubin levels to determine whether they’re in the normal range. High or low bilirubin levels might indicate that some part of the process of breaking down and clearing old red blood cells isn’t working correctly.

What do Direct Bilirubin Test levels indicate?
Beckman Coulter OSR6211 Olympus Direct Bilirubin Reagent Olympus DBil reagent for Direct Bilirubin Test | JIT4You Clinical Lab Consumables
Beckman Coulter OSR6211 Olympus Direct Bilirubin Reagent Olympus DBil reagent for Direct Bilirubin Test

Healthcare providers often give bilirubin tests to check on the health of your liver. The bilirubin test is one of a comprehensive panel of liver function tests that measure different liver products in your blood. If these values are high or low, they might indicate that your liver is struggling in some way. But abnormal bilirubin levels don’t always indicate a problem in your liver. Sometimes it’s somewhere else.

What causes high direct Bilirubin Test levels (hyperbilirubinemia)?

Bilirubin might build up in your blood if:

  • 1.Your body breaks down too many red blood cells too fast. You might be overproducing bilirubin if you have a blood disorder, such as hemolytic anemia, that destroys red blood cells.
  • 2.Your liver is struggling to process its normal load of bilirubin. Your liver might struggle with occasional toxic overload, or it might have a chronic liver disease that affects its functioning.
  • 3.Your biliary system isn’t clearing bile efficiently. There might be a blockage in your bile ducts or your gallbladder that’s causing bile to back up and leak into your bloodstream.
What causes low Direct Bilirubin Test levels (hypobilirubinemia)?

Certain medications can lower your bilirubin levels, including antibioticsbirth control pillssleeping pills and seizure medications. Low levels aren’t generally a cause for concern.

What does bilirubin do human body?

Bilirubin is a waste product of expired red blood cells. Normally, your body expels it through your intestines. On its way out, though, it may provide some benefits. Current studies suggest it may act as an antioxidant that helps protect against cardiovascular disease. However, too much can be toxic. If it builds up in your blood, it can make you feel ill. It can also irritate nerves under your skin, making it itch.

What are symptoms of high bilirubin?

High bilirubin leads to jaundice, a yellow cast to your skin and the whites of your eyes. Jaundice is often the first symptom that would prompt a healthcare provider to check your bilirubin levels. High bilirubin in your blood can also leak out in your pee, making it darker. If bilirubin isn’t coming out in your poop as it should, your poop might be lighter or clay-colored. Very high bilirubin can make you itch (pruritus).